PDX-MI specification paper published

Patient-derived xenografts (PDX) models are an important oncology research tool for the study of tumours. They are created by implanting tumours from cancer patients into a ‘transplant-compliant’ mouse host. PDX are thought to better reflect the heterogeneity of tumours than cell lines or transgenic animal ...

Patient-Derived Xenograft models undergo mouse-specific tumour evolution

PDX models are in vivo systems to study human cancers and tumour therapies. Identifying the correct PDX models for developing drug targets is not an easy task for oncologists. A recent scientific publication in Nature Genetics has highlighted the importance of cataloguing the molecular characterisation ...

New Global PDX Directory introduced at AACR conference

Thursday 26th October... The first Global PDX Directory for proprietary and open source PDX models is being introduced by Cambridge (UK) based benefit corporation, Repositive, at the American Association for Cancer Research’s (AACR) International Conference, on Molecular Targets and Cancer Therapeutics, hosted in conjunction ...

Harnessing Clinical Insights from Tumor Models Boston 2017

Tumor Models Boston 2017 The 5th Annual Tumour Models Boston event aimed to showcase the latest advancements in the application of preclinical models to enhance the translation of cancer therapies from animal to patient! It was clear two of the showcases really stood out for ...

A brief overview of human cancer models

Why study cancer? There is hardly anyone on this planet who has not heard about cancer and has not been in touch with it in this one way or another. It looks like cancer has existed for as long as humanity remembers itself; the views ...